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1

Whole-cell biotransformation assay for investigation of the human drug metabolizing enzyme CYP3A7

Ina Neunzig, Călin-Aurel Drăgan, Maria Widjaja, Andrea E. Schwaninger, Frank T. Peters, Hans H. Maurer, Matthias Bureik

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2011

Language:

english

File:

PDF, 326 KB

english, 2011

2

Glucuronide Production by Whole-Cell Biotransformation Using Genetically Engineered Fission Yeast Schizosaccharomyces pombe

Dragan, C.-A., Buchheit, D., Bischoff, D., Ebner, T., Bureik, M.

Journal:

Drug Metabolism and Disposition

Year:

2010

Language:

english

File:

PDF, 775 KB

english, 2010

3

Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1

Fan, Linbing, Joseph, Jan Felix, Durairaj, Pradeepraj, Parr, Maria Kristina, Bureik, Matthias

Journal:

Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 384 KB

english, 2018

4

Expression of colony‐stimulating factor 1 and interleukin‐34 in gingival tissue and gingival fibroblasts from periodontitis patients and controls

Clark, Reuben, Zwicker, Stephanie, Bureik, Daniela, Johannsen, Gunnar, Boström, Elisabeth A.

Journal:

Journal of Periodontology

Year:

2019

Language:

english

File:

PDF, 908 KB

english, 2019

5

p53 antibodies: Call for quality

Anja Nickels, Matthias Bureik, Mathias Montenarh, Michael Pfreundschuh, Bernhard Koch

Journal:

International Journal of Cancer

Year:

1997

Language:

english

File:

PDF, 28 KB

english, 1997

6

Efficient conversion of 11-deoxycortisol to cortisol (hydrocortisone) by recombinant fission yeast Schizosaccharomyces pombe

Călin-Aurel Drăgan, Silvia Zearo, Frank Hannemann, Rita Bernhardt, Matthias Bureik

Journal:

FEMS Yeast Research

Year:

2005

Language:

english

File:

PDF, 136 KB

english, 2005

7

Challenges of steroid biotransformation with human cytochrome P450 monooxygenase CYP21 using resting cells of recombinant Schizosaccharomyces pombe

Daniela Zehentgruber, Cǎlin-Aurel Drǎgan, Matthias Bureik, Stephan Lütz

Journal:

Journal of Biotechnology

Year:

2010

Language:

english

File:

PDF, 508 KB

english, 2010

8

Human 20α-hydroxysteroid dehydrogenase (AKR1C1)-dependent biotransformation with recombinant fission yeast Schizosaccharomyces pombe

Julia Maria Naumann, Josef Messinger, Matthias Bureik

Journal:

Journal of Biotechnology

Year:

2010

Language:

english

File:

PDF, 955 KB

english, 2010

9

The adrenodoxin-like ferredoxin of Schizosaccharomyces pombe mitochondria

Burkhard Schiffler, Matthias Bureik, Wolfgang Reinle, Eva-Christina Müller, Frank Hannemann, Rita Bernhardt

Journal:

Journal of Inorganic Biochemistry

Year:

2004

Language:

english

File:

PDF, 262 KB

english, 2004

10

Increased TCA cycle activity and reduced oxygen consumption during cytochrome P450-dependent biotransformation in fission yeast

Cǎlin-Aurel Drǎgan, Lars M. Blank, Matthias Bureik

Journal:

Year:

2006

Language:

english

File:

PDF, 413 KB

english, 2006

11

A fluorimetric assay for cortisol

Daniel Appel, Rolf D. Schmid, Calin-Aurel Dragan, Matthias Bureik, Vlada B. Urlacher

Journal:

Analytical and Bioanalytical Chemistry

Year:

2005

Language:

english

File:

PDF, 133 KB

english, 2005

12

ROS production by adrenodoxin does not cause apoptosis in fission yeast

Evi Derouet-Hümbert, Călin-Aurel Drăgan, Tarek Hakki, Matthias Bureik

Journal:

Year:

2007

Language:

english

File:

PDF, 261 KB

english, 2007

13

Expression and Secretion of a CB4-1 scFv–GFP Fusion Protein by Fission Yeast

Julia Maria Naumann, Gabriele Küttner, Matthias Bureik

Journal:

Applied Biochemistry and Biotechnology

Year:

2011

Language:

english

File:

PDF, 284 KB

english, 2011

14

Convenient Gram-Scale Metabolite Synthesis by Engineered Fission Yeast Strains Expressing Functional Human P450 Systems

Călin-Aurel Drăgan, Frank T. Peters, Pierre Bour, Andrea E. Schwaninger, Stefanie M. Schaan, Ina Neunzig, Maria Widjaja, Josef Zapp, Thomas Kraemer, Hans H. Maurer, Matthias Bureik

Journal:

Applied Biochemistry and Biotechnology

Year:

2011

Language:

english

File:

PDF, 509 KB

english, 2011

15

Biotechnological Production of 20-alpha-Dihydrodydrogesterone at Pilot Scale

Julia Maria Naumann, Andy Zöllner, Călin-Aurel Drăgan, Josef Messinger, Joachim Adam, Matthias Bureik

Journal:

Applied Biochemistry and Biotechnology

Year:

2011

Language:

english

File:

PDF, 399 KB

english, 2011

16

The human mineralocorticoid receptor only partially differentiates between different ligands after expression in fission yeast

Matthias Bureik, Nicole Brück, Katja Hübel, Rita Bernhardt

Journal:

FEMS Yeast Research

Year:

2005

Language:

english

File:

PDF, 218 KB

english, 2005

17

Use of fission yeast heterologously expressing human cytochrome P450 2B6 in biotechnological synthesis of the designer drug metabolite N-(1-phenylcyclohexyl)-2-hydroxyethanamine

Frank T. Peters, Calin-A. Dragan, Andrea E. Schwaninger, Christoph Sauer, Josef Zapp, Matthias Bureik, Hans H. Maurer

Journal:

Forensic Science International

Year:

2009

Language:

english

File:

PDF, 160 KB

english, 2009

18

The “bringer” strategy

Andreas Bichet, Matthias Bureik, Natalie Lenz, Rita Bernhardt

Journal:

Applied Biochemistry and Biotechnology

Year:

2004

Language:

english

File:

PDF, 194 KB

english, 2004

19

Vitamin D Analog Calcipotriol Suppresses the Th17 Cytokine–Induced Proinflammatory S100 “Alarmins” Psoriasin (S100A7) and Koebnerisin (S100A15) in Psoriasis

Peric, Mark, Koglin, Sarah, Batycka-Baran, Aleksandra, Prinz, Jörg C, Ruzicka, Thomas, Schauber, Jürgen, Wolf, Ronald, Hegyi, Zuzana, Zwicker, Stephanie, Bureik, Daniela

Journal:

The Journal of Investigative Dermatology

Year:

2012

Language:

english

File:

PDF, 14.21 MB

english, 2012

20

Biotechnological synthesis of drug metabolites using human cytochrome P450 2D6 heterologously expressed in fission yeast exemplified for the designer drug metabolite 4′-hydroxymethyl-α-pyrrolidinobutyrophenone

Frank T. Peters, Calin-A. Dragan, Désirée R. Wilde, Markus R. Meyer, Josef Zapp, Matthias Bureik, Hans H. Maurer

Journal:

Biochemical Pharmacology

Year:

2007

Language:

english

File:

PDF, 281 KB

english, 2007

21

Engineering of Human CYP3A Enzymes by Combination of Activating Polymorphic Variants

Ina Neunzig, Maria Widjaja, Călin-Aurel Drăgan, Frank T. Peters, Hans H. Maurer, Matthias Bureik

Journal:

Applied Biochemistry and Biotechnology

Year:

2012

Language:

english

File:

PDF, 458 KB

english, 2012

22

Development of test systems for the discovery of selective human aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1) inhibitors.: Discovery of a new lead compound for the therapy of congestive heart failure, myocardial fibrosis and hypertension

Matthias Bureik, Katja Hübel, Calin-Aurel Dragan, Jochen Scher, Hans Becker, Natalie Lenz, Rita Bernhardt

Journal:

Molecular and Cellular Endocrinology

Year:

2004

Language:

english

File:

PDF, 176 KB

english, 2004

23

Unexpected contribution of cytochrome P450 enzymes CYP11B2 and CYP21, as well as CYP3A4 in xenobiotic androgen elimination – Insights from metandienone metabolism

Maria Kristina Parr, Andy Zöllner, Gregor Fußhöller, Georg Opfermann, Nils Schlörer, Mirela Zorio, Matthias Bureik, Wilhelm Schänzer

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 752 KB

english, 2012

24

Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells

Peter B Ehmer, Matthias Bureik, Rita Bernhardt, Ursula Müller, Rolf W Hartmann

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2002

Language:

english

File:

PDF, 89 KB

english, 2002

25

Coexpression of redox partners increases the hydrocortisone (cortisol) production efficiency in CYP11B1 expressing fission yeast Schizosaccharomyces pombe

Tarek Hakki, Silvia Zearo, Călin-Aurel Drăgan, Matthias Bureik, Rita Bernhardt

Journal:

Journal of Biotechnology

Year:

2008

Language:

english

File:

PDF, 815 KB

english, 2008

26

Production and NMR analysis of the human ibuprofen metabolite 3-hydroxyibuprofen

Ina Neunzig, Anke Göhring, Călin-Aurel Drăgan, Josef Zapp, Frank T. Peters, Hans H. Maurer, Matthias Bureik

Journal:

Journal of Biotechnology

Year:

2012

Language:

english

File:

PDF, 458 KB

english, 2012

27

CYP21-catalyzed production of the long-term urinary metandienone metabolite 17β-hydroxymethyl-17α-methyl-18-norandrosta-1,4,13-trien-3-one: a contribution to the fight against doping

Zöllner, Andy, Parr, Maria Kristina, Drăgan, Călin-Aurel, Dräs, Stefan, Schlörer, Nils, Peters, Frank T., Maurer, Hans H., Schänzer, Wilhelm, Bureik, Matthias

Journal:

Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 168 KB

english, 2010

28

Inhibition of aldosterone biosynthesis by staurosporine

Bureik, Matthias, Mion, Alexander, Kenyon, Christopher J., Bernhardt, Rita

Journal:

Biological Chemistry

Year:

2005

Language:

english

File:

PDF, 144 KB

english, 2005

29

Coexpression of CPR from Various Origins Enhances Biotransformation Activity of Human CYPs inS. pombe

Neunzig, Ina, Widjaja, Maria, Peters, Frank T., Maurer, Hans H., Hehn, Alain, Bourgaud, FrÃ©dÃ©ric, Bureik, Matthias

Journal:

Applied Biochemistry and Biotechnology

Year:

2013

Language:

english

File:

PDF, 284 KB

english, 2013

30

Overcoming the metabolic burden of protein secretion in Schizosaccharomyces pombe – A quantitative approach using 13C-based metabolic flux analysis

Klein, Tobias, Lange, Sabrina, Wilhelm, Nadine, Bureik, Matthias, Yang, Tae-Hoon, Heinzle, Elmar, Schneider, Konstantin

Journal:

Metabolic Engineering

Year:

2014

Language:

english

File:

PDF, 1.62 MB

english, 2014

31

Synthesis and Evaluation of Imidazolylmethylenetetrahydronaphthalenes and Imidazolylmethyleneindanes: Potent Inhibitors of Aldosterone Synthase

Ulmschneider, Sarah, Müller-Vieira, Ursula, Mitrenga, Markus, Hartmann, Rolf W., Oberwinkler-Marchais, Sandrine, Klein, Christian D., Bureik, Matthias, Bernhardt, Rita, Antes, Iris, Lengauer, Thomas

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 288 KB

english, 2005

32

Phosphorylation of Bovine Adrenodoxin by Protein Kinase CK2 Affects the Interaction with Its Redox Partner Cytochrome P450 scc (CYP11A1) †

Bureik, Matthias, Zöllner, Andy, Schuster, Norbert, Montenarh, Mathias, Bernhardt, Rita

Journal:

Year:

2005

Language:

english

File:

PDF, 288 KB

english, 2005

33

Functional Expression of Human Mitochondrial CYP11B2 in Fission Yeast and Identification of a New Internal Electron Transfer Protein, etp1 †

Bureik, Matthias, Schiffler, Burkhard, Hiraoka, Yasushi, Vogel, Frank, Bernhardt, Rita

Journal:

Year:

2002

Language:

english

File:

PDF, 417 KB

english, 2002

34

A fission yeast-based test system for the determination of IC 50 values of anti-prostate tumor drugs acting on CYP21

Drăgan, Călin-Aurel, Hartmann, Rolf W., Bureik, Matthias

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 313 KB

english, 2006

35

Pentacyclic Triterpenes from Terminalia arjuna Show Multiple Benefits on Aged and Dry Skin

Farwick, M., Köhler, T., Schild, J., Mentel, M., Maczkiewitz, U., Pagani, V., Bonfigli, A., Rigano, L., Bureik, D., Gauglitz, G.G.

Journal:

Skin Pharmacology and Physiology

Year:

2014

Language:

english

File:

PDF, 364 KB

english, 2014

36

Production of Ibuprofen Acyl Glucosides by Human UGT2B7

Buchheit, D., Dragan, C.-A., Schmitt, E. I., Bureik, M.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 1.24 MB

english, 2011

37

Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes

Zöllner, Andy, Buchheit, Daniela, Meyer, Markus R, Maurer, Hans H, Peters, Frank T, Bureik, Matthias

Journal:

Year:

2010

Language:

english

File:

PDF, 933 KB

english, 2010

38

Biotechnological Synthesis of the Designer Drug Metabolite 4'-Hydroxymethyl- -pyrrolidinohexanophenone in Fission Yeast Heterologously Expressing Human Cytochrome P450 2D6--A Versatile Alternative to Multistep Chemical Synthesis

Peters, F. T., Dragan, C.-A., Kauffels, A., Schwaninger, A. E., Zapp, J., Bureik, M., Maurer, H. H.

Journal:

Journal of Analytical Toxicology

Year:

2009

Language:

english

File:

PDF, 270 KB

english, 2009

39

The Antimicrobial Peptides Psoriasin (S100A7) and Koebnerisin (S100A15) Suppress Extracellular Matrix Production and Proliferation of Human Fibroblasts

Gauglitz, Gerd G., Bureik, Daniela, Zwicker, Stephanie, Ruzicka, Thomas, Wolf, Ronald

Journal:

Skin Pharmacology and Physiology

Year:

2014

Language:

english

File:

PDF, 798 KB

english, 2014

40

Human p53 Restores DNA Synthesis Control in Fission Yeast

Bureik, Matthias, Jungbluth, Andreas, Drescher, Rudolf, Wagner, Peter

Journal:

Biological Chemistry

Year:

1997

Language:

english

File:

PDF, 2.79 MB

english, 1997

41

Adrenodoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by the generation of reactive oxygen species in mitochondria

Derouet-Hümbert, Evi, Roemer, Klaus, Bureik, Matthias

Journal:

Biological Chemistry

Year:

2005

Language:

english

File:

PDF, 221 KB

english, 2005

42

Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid

Zöllner, Andy, Dragan, Calin-Aurel, Pistorius, Dominik, Müller, Rolf, Bode, Helge B., Peters, Frank T., Maurer, Hans H., Bureik, Matthias

Journal:

Biological Chemistry

Year:

2009

Language:

english

File:

PDF, 117 KB

english, 2009

43

The Human Steroid Hydroxylases CYP11B1 and CYP11B2

Bureik, M., Lisurek, M., Bernhardt, R.

Journal:

Biological Chemistry

Year:

2002

Language:

english

File:

PDF, 492 KB

english, 2002

44

S-Glucuronidation of 7-mercapto-4-methylcoumarin by human UDP glycosyltransferases in genetically engineered fission yeast cells

Buchheit, Daniela, Schmitt, Ellen I., Bischoff, Daniel, Ebner, Thomas, Bureik, Matthias

Journal:

Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 224 KB

english, 2011

45

Botulinum Toxin A for the Treatment of Keloids

Gauglitz, G.G., Bureik, D., Dombrowski, Y., Pavicic, T., Ruzicka, T., Schauber, J.

Journal:

Skin Pharmacology and Applied Skin Physiology

Year:

2012

Language:

english

File:

PDF, 618 KB

english, 2012

46

Friend or Foe? – Psoriasin und Koebnerisin

Zwicker, S., Bureik, D., Ruzicka, T., Wolf, R.

Journal:

DMW - Deutsche Medizinische Wochenschrift

Year:

2012

Language:

german

File:

PDF, 250 KB

german, 2012

47

Biotechnological synthesis of drug metabolites using human cytochrome P450 isozymes heterologously expressed in fission yeast

Peters, Frank T, Bureik, Matthias, Maurer, Hans H

Journal:

Year:

2009

Language:

english

File:

PDF, 688 KB

english, 2009

48

An additional transcript of the cdc25C gene from A431 cells encodes a functional protein.

Bureik, M, Rief, N, Drescher, R, Jungbluth, A, Montenarh, M, Wagner, P

Journal:

International Journal of Oncology

Year:

2000

Language:

english

File:

PDF, 2.28 MB

english, 2000

49

MODULATION OF STEROID HYDROXYLASE ACTIVITY IN STABLY TRANSFECTED V79MZH11B1 AND V79MZH11B2 CELLS BY PKC AND PKD INHIBITORS

Bureik, Matthias, Zeeh, Annette, Bernhardt, Rita

Journal:

Endocrine Research

Year:

2002

Language:

english

File:

PDF, 357 KB

english, 2002

50

Selective oxidation of UDP-glucose to UDP-glucuronic acid using permeabilizedSchizosaccharomyces pombeexpressing human UDP-glucose 6-dehydrogenase

Weyler, Christian, Bureik, Matthias, Heinzle, Elmar

Journal:

Biotechnology Letters

Year:

2016

Language:

english

File:

PDF, 813 KB

english, 2016